Michel nussenzweig nobel prize

Michel C. Nussenzweig

Brazilian immunologist (born )

Michel C. Nussenzweig (born 10 February ) is a professor and head of the Laboratory of Molecular Immunology at The Rockefeller University and a Howard Hughes Medical Institute investigator.

  • Item 1 of 1
  • Settings
  • Carousel
  • Michel C. Nussenzweig - Wikipedia
  • Ralph M. Steinman – Photo gallery - NobelPrize.org

    • He is a member of both the US National Academy of Medicine and the US National Academy of Sciences.

    Education and career

    Nussenzweig graduated summa cum laude with a B.A. degree from New York University College of Arts and Sciences in He earned a Ph.D. from The Rockefeller University in in cellular immunology, working in Zanvil A.

    Cohn’s laboratory with Ralph M. Steinman on groundbreaking studies of mouse dendritic cells.

    As a Ph.D. student, Nussenzweig was the first to show that dendritic cells present foreign antigens to initiate T cell immunity.[1] He also produced the first dendritic cell-specific monoclonal antibody and cloned the first dendritic cell receptor.[2]

    Nussenzweig received an M.D.

    from New York University School of Medicine in and completed his internship and residency in internal medicine, and a clinical fellowship in infectious diseases at Massachusetts General Hospital in From to , he was a postdoctoral fellow in genetics in the Harvard Medical School laboratory of Philip Leder. Nussenzweig returned to The Rockefeller University as an assistant professor in and he became an associate professor in , and a professor and senior physician in In , he was named the first Zanvil A.

    Cohn and Ralph M. Steinman Professor.[3][4]

    Summary of research achievements

    Nussenzweig studies molecular aspects of the immune system’s adaptive and innate responses, using a combination of biochemistry, molecular biology, and genetics. Work on adaptive immunity focuses on B lymphocytes and antibodies to HIV-1, while work on innate immunity focuses on dendritic cells.[5] The laboratory has isolated and cloned human antibodies to HIV-1 and explored their roles in prevention and therapy.

    Michel nussenzweig nobel prize winners This is the third consecutive year that a Rockefeller scientist has won the Robert Koch Award. Nature , — The Rockefeller University. News from The National Academies.

    In clinical trials, a broadly neutralizing antibody isolated from an HIV-infected patient was shown to be safe and effective and to interfere with chronic infection in a way that traditional antiretroviral therapy does not.[6][7] His research has led to the development of innovative vaccines against infectious diseases and new treatments for autoimmunity.[8][9]

    Awards and honors

    • American Association of Immunologists Meritorious Career Award, [10]
    • American Academy of Arts and Sciences, [11]
    • Lee C.

      Howley Sr. Prize for Arthritis Research, [12]

    • National Academy of Medicine, [13]
    • National Academy of Sciences, [14]
    • Brazilian Academy of Sciences, [15]
    • Nobel Prize Lecture on behalf of Ralph Steinman, [16]
    • Brazil Diaspora Prize, [17]
    • Spanish Royal Academy, [18]
    • Rabbi Shai Shacknai Memorial Prize in Immunology and Cancer Research, [19]
    • Robert Koch Award, [20]
    • AAI-BioLegend Herzenberg Award, [21]
    • Sanofi-Institut Pasteur Award, [22]

    References

    1. ^Nussenzweig, M.

      C.; Steinman, R. M. (1 May ). "Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction". The Journal of Experimental Medicine. (5): – doi/jem ISSN&#; PMC&#; PMID&#;

    2. ^Nussenzweig, M C; Steinman, R M; Witmer, M D; Gutchinov, B (1 January ). "A monoclonal antibody specific for mouse dendritic cells".

      Proceedings of the National Academy of Sciences of the United States of America.

    3. Nobel prize categories
    4. Michel nussenzweig nobel prize speech
    5. Nobel prize literature

      6. 79 (1): – BibcodePNASN. doi/pnas ISSN&#; PMC&#; PMID&#;

    6. ^"Heads of Laboratory: Michel C. Nussenzweig". The Rockefeller University. Retrieved 16 Aug
    7. ^"Immunity and Tolerance".

      Nobel prize categories: People who receive monoclonal antibodies before vaccines may benefit from increased coverage, due to antibody feedback inhibition. In clinical trials conducted at The Rockefeller University Hospital, two of these antibodies interfered with chronic HIV infection, driving the amount of virus in the blood to below detectable levels. Steinman on groundbreaking studies of mouse dendritic cells. As part of that effort, his laboratory has devised strategies to isolate, analyze, and produce highly potent human antibodies capable of neutralizing multiple HIV strains.

      Howard Hughes Medical Institute. Retrieved 16 Aug

    8. ^Scheid, Johannes F.; Mouquet, Hugo; Feldhahn, Niklas; Seaman, Michael S.; Velinzon, Klara; Pietzsch, John; Ott, Rene G.; Anthony, Robert M.; Zebroski, Henry; Hurley, Arlene; Phogat, Adhuna; Chakrabarti, Bimal; Li, Yuxing; Connors, Mark; Pereyra, Florencia; Walker, Bruce D.; Wardemann, Hedda; Ho, David; Wyatt, Richard T.; Mascola, John R.; Ravetch, Jeffrey V.; Nussenzweig, Michel C.

      (2 April ). "Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals". Nature. (): – BibcodeNaturS. doi/nature PMID&#; S2CID&#;

    9. ^Halper-Stromberg, Ariel; Lu, Ching-Lan; Klein, Florian; Horwitz, Joshua A.; Bournazos, Stylianos; Nogueira, Lilian; Eisenreich, Thomas R.; Liu, Cassie; Gazumyan, Anna; Schaefer, Uwe; Furze, Rebecca C.; Seaman, Michael S.; Prinjha, Rab; Tarakhovsky, Alexander; Ravetch, Jeffrey V.; Nussenzweig, Michel C.

      (28 August ). "Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice". Cell.

      Nobel live In clinical trials conducted at The Rockefeller University Hospital, a broadly neutralizing antibody, 3BNC, which had been isolated from an HIV-infected patient whose immune system had an exceptional ability to neutralize HIV in the blood, was shown to interfere with chronic HIV infection in ways that traditional antiretroviral therapy does not, suggesting it might lead to long-term control of the virus. Michel C. People who receive monoclonal antibodies before vaccines may benefit from increased coverage, due to antibody feedback inhibition. Cohn and Ralph M.

      (5): – doi/ PMC&#; PMID&#;

    10. ^Scheid, Johannes F.; et&#;al. (28 July ). "HIV-1 antibody 3BNC suppresses viral rebound in humans during treatment interruption". Nature. (): – BibcodeNaturS. doi/nature PMC&#; PMID&#;
    11. ^Lu, Ching-Lan; Murakowski, Dariusz K.; Bournazos, Stylianos; Schoofs, Till; Sarkar, Debolina; Halper-Stromberg, Ariel; Horwitz, Joshua A.; Nogueira, Lilian; Golijanin, Jovana; Gazumyan, Anna; Ravetch, Jeffrey V.; Caskey, Marina; Chakraborty, Arup K.; Nussenzweig, Michel C.

      (20 May ). "Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo". Science. (): – BibcodeSciL. doi/ ISSN&#; PMC&#; PMID&#;

    12. ^Schoofs, Till; Klein, Florian; Braunschweig, Malte; Kreider, Edward F.; Feldmann, Anna; Nogueira, Lilian; Oliveira, Thiago; Lorenzi, Julio C.

      C.; Parrish, Erica H.; Learn, Gerald H.; West, Anthony P.; Bjorkman, Pamela J.; Schlesinger, Sarah J.; Seaman, Michael S.; Czartoski, Julie; McElrath, M. Juliana; Pfeifer, Nico; Hahn, Beatrice H.; Caskey, Marina; Nussenzweig, Michel C. (20 May ). "HIV-1 therapy with monoclonal antibody 3BNC elicits host immune responses against HIV-1".

      Science. (): – BibcodeSciS. doi/ ISSN&#; PMC&#; PMID&#;

    13. ^"AAI-Thermo Fisher Meritorious Career Award".

      Michel nussenzweig nobel prize for literature Bibcode : Sci As part of that effort, his laboratory has devised strategies to isolate, analyze, and produce highly potent human antibodies capable of neutralizing multiple HIV strains. Scientific career. More news Browse our recent stories.

      Retrieved 14 July

    14. ^"Twelve Howard Hughes Medical Institute Scientists Elected to American Academy of Arts and Sciences". Howard Hughes Medical Institute. Retrieved 15 August
    15. ^"Past Howley Prize Recipients". Retrieved 18 July
    16. ^"Institute of Medicine Elects 65 New Members, Five Foreign Associates".

      News from The National Academies. Retrieved 15 August

    17. ^"Michel C. Nussenzweig elected to National Academy of Sciences". 3 May Retrieved 16 August
    18. ^"Eleitos novos membros da ABC" [Newly Elected Members of the ABC] (in Portuguese). 16 December Retrieved 14 July
    19. ^"Nobel Lecture ".

      The Official Site of the Nobel Prize. Retrieved 18 September

    20. ^"Prêmio Diáspora Brasil divulga vencedores" (in Portuguese). Retrieved 16 August
    21. ^"Toma de Posesión de Académico de Honor del Excmo. Sr. D. Michel C. Nussenzweig".

      Michel nussenzweig nobel prize Steinman on groundbreaking studies of mouse dendritic cells. Nobel-prizewinner Ralph Steinman tried to beat his cancer with vaccines based on the dendritic cells he discovered. Nature , — Retrieved 15 August

      Real Academia Nacional de Farmacia (in Spanish). 11 April Retrieved 16 August

    22. ^"The Rabbi Shai Shacknai Memorial Lecture in Immunology and Cancer Research"(PDF). The Hebrew University of Jerusalem Faculty of Medicine. Retrieved 16 August
    23. ^"With their outstanding research, laureates lay the foundation for understanding the way in which different immunological mechanisms function".

      22 June Retrieved 18 July

    24. ^"AAI-BioLegend Herzenberg Award Past Recipients". The American Association of Immunologists. Retrieved 7 March
    25. ^"JEM Editorial Board Co-Chair wins Sanofi-Institut Pasteur Award". Journal of Experimental Medicine. 12 December Retrieved 5 March